The British journal of surgery
-
Comment Letter Randomized Controlled Trial Clinical Trial
Randomized comparison of the neuroendocrine response to laparoscopic cholecystectomy using either the conventional or abdominal wall lift techniques.
-
Randomized Controlled Trial Multicenter Study Clinical Trial
Radical surgery and postoperative radiotherapy as combined treatment in rectal cancer. Final results of a phase III study of the European Organization for Research and Treatment of Cancer.
There is controversy whether adjuvant radiotherapy should be given before or after surgery for locally advanced, resectable rectal cancer. Preoperative radiotherapy substantially reduces local recurrence rates but may increase postoperative complications. In addition, patients found to have early cancers are treated unnecessarily. This study is a randomized trial of postoperative radiotherapy in patients who had a potentially curative resection for locally advanced rectal carcinoma. ⋯ This trial failed to demonstrate any improvement in overall survival or local control when postoperative irradiation was given following resection of locally advanced rectal carcinoma.