Current opinion in clinical nutrition and metabolic care
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The present review addresses data from randomized clinical trials on perioperative nutrition in patients with gastrointestinal cancer. It is important to appreciate that different approaches can be used with regard to timing of administration of nutritional support (preoperative versus postoperative), route of administration (parenteral versus enteral) and composition of the admixtures given (standard versus immune-enriched diets). The rationale underlying these approaches may also vary, and may include correction of nutritional status, attenuation of the acute-phase response through better preservation of gut function, and potentiation of the immune response.
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The gut has often been suggested to be one of the essential factors in the pathogenesis of many nosocomial infections and possibly multi-organ failure. In the light of several recent studies, the importance of normal gut bacterial flora and the role of the gastrointestinal tract in human immune function are now better understood. It now seems clear that stimulation of gut-associated lymphoid tissue through enteral feeding is the key to the preservation of mucosal-derived immunity; however, the role of this native gastrointestinal immune function in the subsequent development of sepsis and multi-organ dysfunction syndrome remains the subject of ongoing study.
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Women generally have a higher percentage of body fat than men. Also, women store more fat in the gluteal-femoral region, whereas men store more fat in the visceral (abdominal) depot. This review focuses on differences in regional fatty acid storage, mobilization and oxidation that may contribute to gender-related differences in body fat distribution. ⋯ Furthermore, there is abundant evidence that the proportion of energy derived from fat during exercise is higher in women than in men. With respect to total body fat, this finding seems counterintuitive, as percentage body fat is increased in women. Further studies are necessary to investigate the significance of differences in exercise-induced fat oxidation on 24-h fat balance.