Current opinion in clinical nutrition and metabolic care
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Curr Opin Clin Nutr Metab Care · Nov 2013
ReviewZinc in traumatic brain injury: from neuroprotection to neurotoxicity.
In light of the recent recognition that even mild forms of traumatic brain injury (TBI) can lead to long-term cognitive and behavioral deficits, this review examines recent data on the neuroprotective and neurotoxic roles of zinc after brain injury. ⋯ This work shows the need for future research to clarify the potentially contradictory roles of zinc in the hippocampus and define the clinical use of zinc as a treatment following brain injury in humans. This is particularly important given the finding that zinc may reduce TBI-associated depression, a common and difficult outcome to treat in all forms of TBI.
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Curr Opin Clin Nutr Metab Care · Nov 2013
ReviewUpdate on antioxidant micronutrients in the critically ill.
To evaluate recent evidence on pharmaconutrition with antioxidant micronutrients, for different populations of adult critically ill patients. ⋯ There is evidence supporting the concept of pharmaconutrition with high-dose micronutrients. Selenium therapy may be able to decrease infections and reduce mortality in sepsis, but more research is needed to better understand pharmacokinetics, optimal composition, timing, duration, and dose of antioxidant cocktails for the critically ill.