Current opinion in clinical nutrition and metabolic care
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Curr Opin Clin Nutr Metab Care · Mar 2017
ReviewInfluence of nutrition therapy on the intestinal microbiome.
This review describes the relationship between nutritional therapies and the intestinal microbiome of critically ill patients. ⋯ Focus of research is shifting toward strategies that augment the intestinal environment to facilitate growth of beneficial microorganisms, strengthen colonization resistance, and maintain immune homeostasis.
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Curr Opin Clin Nutr Metab Care · Mar 2017
ReviewSphingolipids, ORMDL3 and asthma: what is the evidence?
Genome-wide association studies identified ORMDL3, a protein of the endoplasmic reticulum, as a significant asthma risk factor. ORMDL3 is one of three ORMDL proteins that integrate multiple signals to maintain sphingolipid homeostasis. Studies that investigated potential mechanisms for how increased ORMDL3 might affect asthma are summarized. ⋯ Possible mechanisms how ORMDL3 affects asthma include inhibition of sphingolipid synthesis, synergistic effects with known allergens and a combination of both.