Regional anesthesia and pain medicine
-
Reg Anesth Pain Med · Mar 2013
Randomized Controlled TrialA prospective, randomized, blinded study of continuous ropivacaine infusion in the median sternotomy incision following cardiac surgery.
The aim of this prospective, randomized, double-blind, placebo controlled trial was to evaluate the safety and efficacy of continuous ropivacaine infusion of into the sternal wound. ⋯ The phase III trial did not show improvement in time to extubation of the trachea or pain control in the 0.3% ropivacaine group, but it was stopped early by the data safety monitoring board.
-
Reg Anesth Pain Med · Mar 2013
Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal Sirt1.
Little research has been conducted regarding the implications of Sirt1 (a classic III HDAC) in neuropathic pain. The aim of this study was to investigate the variation in the expressions of spinal Sirt1 and acetyl-histone H3 in a rat model of chronic constriction injury. ⋯ Our data provide new evidence for the contribution of spinal Sirt1 to the initiation and maintenance of neuropathic pain. The antinociceptive effects of resveratrol may be mediated through the activation of spinal Sirt1 in CCI rats.