Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Jul 2017
Biochemical and Pharmacological Characterization of a Mice Model of Complex Regional Pain Syndrome.
Complex regional pain syndrome is a challenging disease to treat. Recently, a mouse fracture model of complex regional pain syndrome has been developed that has many signs of the clinical syndrome. However, many aspects of the sensory neuron biochemistry and behavioral and pharmacological characterization of this model remain to be clarified. ⋯ Persistent pain-related behavior was demonstrated in this mouse fracture/cast model with wide-scale DRG up-regulation of pain mediators. Antihyperalgesic drugs reduced mechanical allodynia and improved burrowing.