Regional anesthesia and pain medicine
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Reg Anesth Pain Med · Mar 2013
Randomized Controlled Trial Comparative StudyPharmacokinetics of sublingual sufentanil tablets and efficacy and safety in the management of postoperative pain.
A sublingual sufentanil tablet is being developed as a potential alternative to intravenous (IV) opioids for the management of postoperative pain. The objective of these studies was to evaluate the pharmacokinetics, efficacy, and safety of sublingual sufentanil tablets for postoperative pain management. ⋯ Sufentanil formulated as a sublingual solid dosage form provides a duration of action that allows effective analgesia for postoperative patients in a medically supervised setting.
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Reg Anesth Pain Med · Mar 2013
Randomized Controlled TrialThe effect of bench model fidelity on fluoroscopy-guided transforaminal epidural injection training: a randomized control study.
The purpose of this study was to determine whether high-fidelity simulators provide greater benefit than low-fidelity models in training fluoroscopy-guided transforaminal epidural injection. ⋯ Training an epidural procedure using a low-fidelity model may be equally effective as training on a high-fidelity model. These results are consistent with previous research on a variety of interventional procedures and further demonstrate the potential impact of simple, low-fidelity training models.
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Reg Anesth Pain Med · Mar 2013
Letter Randomized Controlled TrialContinuous interscalene nerve block following adhesive capsulitis manipulation.
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Reg Anesth Pain Med · Mar 2013
Thermal hyperalgesia after sciatic nerve block in rat is transient and clinically insignificant.
Ropivacaine has been associated with transient heat hyperalgesia in sciatic nerve blocks in rat. The goal of the present study was to evaluate the hypothesized presence of transient heat hyperalgesia after perineural injection of ropivacaine with a secondary subanalysis of 2 published studies. ⋯ Although statistically significant, the single time point measurement represented only an 11% change from baseline and was no longer present 30 minutes later. These data support the need for a reevaluation of the interpretation that pain can be worsened by perineural ropivacaine injection.
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Reg Anesth Pain Med · Mar 2013
Inflammatory response after injection of aqueous gel into subarachnoid space in piglets.
Ultrasound-guided neuraxial anesthesia requires the application of ultrasound gel between the transducer and the skin to avoid signal drop-off. As the needle is inserted, the gel may be introduced intrathecally. The purpose of this study was to examine the evidence of an inflammatory response in the subarachnoid space after intrathecal gel introduction. ⋯ Subarachnoid injection of ultrasound gel in piglets results in an inflammatory response within neuraxial space.