Nature neuroscience
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Nature neuroscience · Dec 2019
Affective memory rehearsal with temporal sequences in amygdala neurons.
Affective learning and memory are essential for daily behavior, with both adaptive and maladaptive learning depending on stimulus-evoked activity in the amygdala circuitry. Behavioral studies further suggest that post-association offline processing contributes to memory formation. ⋯ These sequences occurred throughout the long post-trial period, contained valence-related information, declined as learning progressed and were selectively present in activity evoked by the recent pairing of a conditioned stimulus with an unconditioned stimulus. Our findings reveal that temporal sequences across neurons in the primate amygdala serve as a coding mechanism and might aid memory formation through the rehearsal of the recently experienced association.