Journal of physiology and biochemistry
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J. Physiol. Biochem. · Sep 2014
Effects of dietary sea cucumber saponin on the gene expression rhythm involved in circadian clock and lipid metabolism in mice during nighttime-feeding.
In mammals, clock rhythms exist not only in the suprachiasmatic nucleus, which is entrained by light/dark (LD) cycles, but also in most peripheral tissues. Recent studies have revealed that most physiology and behavior are subject to well-controlled daily oscillations; similarly, metabolic state influences the diurnal rhythm too. Previous studies have indicated that dietary sea cucumber saponin (SCS) could improve glucose and lipid metabolism of rodent. ⋯ The results showed that dietary SCS caused alteration in rhythms and/or amplitudes of clock genes was more significant in brain than in liver. In addition, peroxisome proliferator-activated receptor (PPARα), sterol regulatory element binding protein-1c (SREBP-1c), together with their target genes carnitine palmitoyl transferase (CPT), and fatty acid synthase (FAS) showed marked changes in rhythm and/or amplitude in SCS group mice. These results suggested that SCS could affect the daily expression patterns of clock genes in brain and liver tissues, and alter the clock-controlled genes involved in lipid metabolism.
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J. Physiol. Biochem. · Sep 2014
Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons.
Brain ischemia appears to be associated with innate immunity. Recent reports showed that C3a and C5a, as potent targets, might protect against ischemia induced cell death. In traditional Chinese medicine, the fruit of Schizandra chinesis Baill (Fructus schizandrae) has been widely used as a tonic. ⋯ Mechanism studies suggested that the modulation of extracellular-regulated kinase (ERK), c-Jun NH2-terminal kinases (JNK), and p38, as well as caspase-3 activity played an important role on the progress of neuronal apoptosis. C5aR participated in the neuroprotective effect of schizandrin A in primary culture of rat cortical neurons after OGD/R. Our findings suggested that schizandrin A might act as a candidate therapeutic target drug used for brain ischemia and related diseases.