Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
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Smoking-related cancer and other disease account for more than 400,000 U. S. deaths annually. Smoking cessation reduces smoking-related disease rates, but relapse rates are high. ⋯ Relative to own brand, Advance reduced exposure to the nitrosamine NNK and CO, and Eclipse reduced exposure to nicotine and the nitrosamine NNK, increased exposure to CO, and resulted in larger, longer, and more frequent puffs. No smoking reduced exposure to the nitrosamine NNK, CO, and nicotine, whereas withdrawal was elevated (all p values <.05). Clinical laboratory evaluation of PREPs for smokers is valuable for measuring users' smoke toxicant exposure, withdrawal, and smoking behavior and should be incorporated into a comprehensive PREP evaluation strategy.