Biological research for nursing
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Management of airway inflammation requires proper monitoring and treatment to improve long-term outcomes. However, achieving this goal is difficult, as current methods have limitations. Although nitric oxide (NO) was first identified 200 years ago, its physiological importance was not recognized until the early 1980s. ⋯ Consequently, there is growing interest in the use of exhaled NO in the management of asthma and other pulmonary conditions. The purpose of this review is to promote a basic understanding of the physiologic actions of NO, measurement techniques, and ways that research findings might translate to future application in clinical practice. Specifically, the article will review the role of exhaled NO in regard to its historical background, mechanisms of action, measurement techniques, and implications for clinical practice and research.
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Randomized Controlled Trial Comparative Study
Effects of endotracheal tube suctioning on arterial oxygen tension and heart rate variability.
The purpose of this study was to examine the autonomic mechanisms underlying changes in heart rate (HR) and systolic blood pressure (SBP) responses to endotracheal tube (ETT) suctioning and to compare the open versus closed methods of ETT suctioning on these measures and on arterial oxygen tension. Eighteen orally intubated participants, 33 to 82 years of age (M = 60 years), were randomized for the order of suctioning method. Arterial oxygen tension (PaO2) was measured before suctioning and 30 s and 5 min following suctioning. ⋯ However, there was a decrease in the parasympathetic nervous system indicator of HR variability (HRV) following open suctioning. All patients in this study maintained a PaO2 level 80 mm Hg, which may account for our lack of significant autonomic changes. This suggests that hyperoxygenation with 100% oxygen for a minimum of 1 min (or 20 breaths), as delivered by preoxygenation modes available on most microprocessor ventilators, should be the method of choice for all hyperoxygenation procedures to avoid a decrease in PaO2 following suctioning.