Canadian journal of physiology and pharmacology
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Can. J. Physiol. Pharmacol. · Aug 2013
ReviewCardioprotection against myocardial reperfusion injury: successes, failures, and perspectives.
The past few decades have witnessed an enormous number of research strategies aimed at protecting the heart against myocardial ischemia-reperfusion injury. Several randomized clinical trials are nowadays in progress testing whether promising therapeutic strategies aimed at preventing lethal reperfusion injury can be translated from bench to bedside. ⋯ These limitations include clinical setting, patient profile, drug administration, and methods for evaluating treatment efficacy. Identifying potential mechanistic and methodological pitfalls in the field may improve future translational research.