Med Phys
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High-resolution MR images can depict rich details of brain anatomical structures and show subtle changes in longitudinal data. 7T MRI scanners can acquire MR images with higher resolution and better tissue contrast than the routine 3T MRI scanners. However, 7T MRI scanners are currently more expensive and less available in clinical and research centers. To this end, we propose a method to generate super-resolution 3T MRI that resembles 7T MRI, which is called as 7T-like MR image in this paper. ⋯ We propose a novel method for prediction of high-resolution 7T-like MR images from low-resolution 3T MR images. Our predicted 7T-like MR images demonstrate better spatial resolution compared to 3T MR images, as well as prediction results by other comparison methods. Such high-quality 7T-like MR images could better facilitate disease diagnosis and intervention.
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Recent pulmonary imaging research has revealed that in patients with chronic obstructive pulmonary disease (COPD) and asthma, structural and functional abnormalities are spatially heterogeneous. This novel information may help optimize treatment in individual patients, monitor interventional efficacy, and develop new treatments. Moreover, by automating the measurement of regional biomarkers for the 19 different anatomical lung segments, there is an opportunity to embed imaging biomarkers into clinically acceptable clinical workflows and improve lung disease clinical care. Therefore, to exploit the regional structure-function information provided by thoracic imaging, and as a first step toward this goal, our objective was to develop a fully automated registration pipeline for thoracic x-ray computed tomography (CT) and inhaled gas functional magnetic resonance imaging (MRI) whole lung and segmental structure-function biomarkers. ⋯ For a diverse group of patients with COPD and asthma, whole lung and segmental VDP was measured using an automated lung image analysis pipeline which provides a way to incorporate lung functional biomarkers into clinical research and patient care.