Nuklearmed Nucl Med
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Nuklearmed Nucl Med · Mar 1988
Comparative Study[Comparison of 99m Tc-HMPAO-labeled leukocytes and 99m Tc-nanocolloid in osteomyelitis].
Six patients with proven or suspected osteomyelitis were studied with both 99mTc-HMPAO-labelled leukocytes and 99mTc-nanocolloid. In all cases the findings of both procedures were in good agreement. ⋯ Two patients showed slightly increased accumulation of both agents and in one patient the finding was (correctly) negative. Further studies are necessary to determine whether or not colloid scintigraphy might replace the time-consuming leukocyte scintigraphy.
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Nuklearmed Nucl Med · Feb 1988
Comparative StudyLocalization of 99mTc-diphosphonates in newly formed bone matrix as a measure of bone lesion detectability.
The lesion-to-normal-bone ratios of DBA-MDP (dibutylamino-methylene-diphosphonate), DPD (dicarboxypropane-diphosphonate) and MDP (methylene-diphosphonate) each labeled with 99mTc, were evaluated in experimental bone lesions. In 3-day old lesions this ratio was increased twofold for DBA-MDP in comparison with MDP and DPD which showed nearly equal ratios. Later on these differences became negligibly small. It is concluded that 99mTc-DBA-MDP is fixed more strongly in the immature bone matrix and that this will lead to an improvement in the detectability of lesions containing larger amounts of immature bone matrix.
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Nuklearmed Nucl Med · Aug 1982
Comparative StudyBiokinetics of bone tracers by means of deconvolution analysis--comparison of 99mTc MDP, 99mTc DPD and 99mTc EHDP.
Transfer functions of 99mTc methylene diphosphonate (MDP), 99mTc 2,3-dicarboxypropane-1,1-diphosphonate (DPD) and 99mTc ethane-1-hydroxy-1,1-diphosphonate (EHDP) into bone and extravascular fluid of soft tissues were determined in 5 dogs by deconvolution analysis of the time-course of plasma, soft tissue and bone radioactivity. The transfer rates 5 min after injection--indicating the rapid exchange of the tracer between plasma and the extravascular fluid--decrease in the order MDP greater than EHDP greater than DPD (P less than 0.05). The transfer rates into bone--determined from transfer rates between 30 and 60 min--decreased in a different order, i.e. ⋯ The fractional bone uptake of diphosphonates estimated from the ratio of early to late transfer rates was slightly greater for DPD than for MDP and EHDP respectively. The difference between DPD and MDP was not significant (P greater than 0.05). The average bone and soft tissue concentrations of DPD 60 min after injection were greater than that of MDP and EHDP due to different plasma concentrations (DPD greater than EHDP greater than MDP), whereas the bone-to-soft tissue ratios decreased in the sequence MDP greater than DPD greater than EHDP (P less than 0.05).--Our results reveal different biokinetics of MDP, DPD and EHDP explaining variations in osseous and soft tissue uptake suggesting that deconvolution analysis could play an important role in bone scan interpretation.
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Nuklearmed Nucl Med · Jun 1976
Case Reports Comparative Study[Demonstration total brain infarct with radioisotope angiography].
In the field of organ transplantation and in brain death patients where intensive-care measures may seem superfluous, the demonstration of cessation of cerebral blood flow by X-ray angiography is generally agreed to be the diagnostic procedure of choice to prove irreversible loss of cerebral function. There are, however, certain drawbacks involved in X-ray angiography. Arterial puncture is necessary. ⋯ In 12 patients with extremely reduced cerebral blood flow it was demonstrated that the RIA findings were clearly different from those obtained at brain death. Moreover, not one of 438 other patients undergoing RIA exhibited the same features which were associated with brain death. The authors conclude that RIA involves the same degree of safety as X-ray angiography in the diagnosis of total brain infarction but is superior to the latter when the diagnostic procedure has to be performed quickly, thus reducing the risk of any further damage to a prospective donor organ.