Clinical pharmacology and therapeutics
-
Clin. Pharmacol. Ther. · Sep 1994
Clinical Trial Controlled Clinical TrialPharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil.
We determined the possible benefits of a new opioid, trefentanil, relative to fentanyl and alfentanil using high-resolution pharmacokinetic-pharmacodynamic modeling and computer simulations of clinical dosing scenarios. ⋯ We suggest that high-resolution pharmacokinetic-pharmacodynamic studies and computer simulations of clinical dosing scenarios may have significant usefulness in appreciating differences between new and established drugs in early phase I studies.