Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Dec 1995
Topographic electroencephalogram of propofol-induced conscious sedation.
To determine the effects of increasing doses of propofol that induce conscious sedation on the topographic electroencephalogram (EEG) of human volunteers and to test the hypothesis that more frontal brain areas are affected by low doses of propofol. ⋯ Topographic brain EEG mapping techniques indicate that frontal brain beta 1 EEG activity may be useful as an objective brain index of propofol conscious sedation.
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Clin. Pharmacol. Ther. · Dec 1995
Ceftazidime pharmacokinetics in preterm infants: effects of renal function and gestational age.
The objectives of this study were (1) to determine the effects of gestational age on ceftazidime pharmacokinetics in the preterm infant, (2) to relate these effects to changes in glomerular filtration rate (GFR), and (3) to establish appropriate dosage recommendations for preterm infants on day 3 of life. ⋯ Dosage recommendations for ceftazidime administration in preterm infants during the first week of life should be based on gestational age and GFR. Additional adjustments in dosage are indicated in preterm infants who are exposed prenatally to indomethacin.