Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Dec 1996
Clinical Trial Controlled Clinical TrialPopulation pharmacodynamic model for ketorolac analgesia.
To derive a population pharmacokinetic-pharmacodynamic model that characterizes the distribution of pain relief scores and remedication times observed in patients receiving intramuscular ketorolac for the treatment of moderate to severe postoperative pain. ⋯ A population pharmacokinetic-pharmacodynamic model for the analgesic efficacy of intramuscular ketorolac was derived. The simulated relationship between dose, time, and percentage of patients with adequate pain relief suggested that 30 mg intramuscular ketorolac was the optimal initial dose for postoperative pain relief.