Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Aug 1997
Randomized Controlled Trial Clinical TrialIncreased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure.
To evaluate the safety and efficacy of low-dose dopamine, high-dose furosemide, and their combination in the treatment of refractory congestive heart failure. ⋯ Combined low-dose intravenous dopamine and oral furosemide have similar efficacy but induce less renal impairment and hypokalemia than higher doses of intravenous furosemide taken either alone or with low-dose dopamine. The renal impairment induced by intravenous furosemide is probably related to its hypotensive effect in patients with refractory congestive heart failure.