Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Mar 1998
Randomized Controlled Trial Clinical TrialDose-related effects of oral acetaminophen on cold-induced pain: a double-blind, randomized, placebo-controlled trial.
The cold-pressor test is a widely used pain-induction model in humans. This method has been shown to be a sensitive measure for detecting opioid analgesia. However, nonsteroidal anti-inflammatory drugs have not produced consistent analgesic effects with use of this model. ⋯ There were statistically significant main effects of both dose and time (pain and bothersomeness ratings decreased with increasing drug dose and increased over time). In pairwise comparisons only the contrast between the highest dose of acetaminophen (1000 mg) and placebo reached statistical significance. Results from our study suggest that the cold-pressor method may have clinical value in evaluating nonopioid analgesic agents.