Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Jun 1999
The effect of age on the pharmacokinetics and pharmacodynamics of midazolam.
We investigated the pharmacologic properties of midazolam with special regard to age using the electroencephalogram (EEG) as a measure of the hypnotic-sedative effect. ⋯ These results suggest that the lower doses needed to reach sedation in the elderly subjects were attributable to a 50% decrease in EC50, not to changes in pharmacokinetics.