Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Aug 1999
Randomized Controlled Trial Clinical TrialPropofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.
To examine the effect of propofol on the pharmacokinetics of midazolam in vivo and to elucidate the mechanism of the pharmacokinetic changes of midazolam by propofol with the use of human liver microsomes and recombinant CYP3A4. ⋯ Propofol decreases the clearance of midazolam, and the possible mechanism is the competitive inhibition of hepatic CYP3A4.