Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Sep 2001
Randomized Controlled Trial Comparative Study Clinical TrialGender and the placebo analgesic effect in acute pain.
Our objective was to examine the placebo arms from a series of clinical trials in which the post-third molar extraction dental pain model was used to elucidate the time course of the placebo effect and the proportion of the population that are responders, as well as to evaluate whether the placebo analgesic response of female subjects may differ from that of male subjects. ⋯ The results demonstrated no gender difference in response to placebo. These results were obtained from the post-third molar extraction situation, in which the least possible confounding factors were present. To fully establish the generality of this phenomenon, studies should be carried out in other pain models.