Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Jun 2004
Randomized Controlled Trial Comparative Study Clinical Trial6'7'-Dihydroxybergamottin contributes to the grapefruit juice effect.
Our objective was to assess the contribution of 6',7'-dihydroxybergamottin (DHB) to the inhibitory effect of grapefruit juice toward intestinal cytochrome P450 (CYP) 3A4. ⋯ The interaction between grapefruit juice serum and felodipine can be attributed largely to DHB. This establishes DHB as an important contributor to the grapefruit juice effect.
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Clin. Pharmacol. Ther. · Jun 2004
Randomized Controlled Trial Comparative Study Clinical TrialEffect of St John's wort dose and preparations on the pharmacokinetics of digoxin.
St John's wort preparations vary in composition, main constituents, formulation, and daily dose administered. The aim of the study was to evaluate the possible pharmacokinetic interaction of marketed St John's wort formulations and doses with digoxin. ⋯ The interaction of St John's wort and digoxin varies within St John's wort preparations and doses and seems to be correlated with the dose, particularly of hyperforin.