Clinical pharmacology and therapeutics
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Clin. Pharmacol. Ther. · Jun 2006
Clinical TrialPharmacokinetics of midazolam, propofol, and fentanyl transfer to human breast milk.
Lactating women undergoing operations requiring general anesthesia are advised to pump and discard their milk for 24 hours after the procedure. Data on anesthetic drug transfer into breast milk are limited. This study determined the pharmacokinetics of midazolam, propofol, and fentanyl transfer into milk to provide caregivers with data regarding the safety of breast milk after administration of these drugs. ⋯ The amount of midazolam, propofol, and fentanyl excreted into milk within 24 hours of induction of anesthesia provides insufficient justification for interrupting breast-feeding.