Circulation research
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Circulation research · Jan 2012
Acidosis dilates brain parenchymal arterioles by conversion of calcium waves to sparks to activate BK channels.
Acidosis is a powerful vasodilator signal in the brain circulation. However, the mechanisms by which this response occurs are not well understood, particularly in the cerebral microcirculation. One important mechanism to dilate cerebral (pial) arteries is by activation of large-conductance, calcium-sensitive potassium (BK(Ca)) channels by local Ca(2+) signals (Ca(2+) sparks) through ryanodine receptors (RyRs). However, the role of this pathway in the brain microcirculation is not known. ⋯ These results support the novel concept that acidification, by converting Ca(2+) waves to sparks, leads to the activation of BK(Ca) channels to induce dilation of cerebral PAs.
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Circulation research · Jan 2012
Randomized Controlled TrialSTAT5 activation and cardioprotection by remote ischemic preconditioning in humans: short communication.
The heart can be protected from infarction by brief episodes of ischemia/reperfusion of a remote organ. Remote ischemic preconditioning (RIPC) by brief arm ischemia/reperfusion has been recruited in patients undergoing coronary artery bypass surgery or percutaneous coronary interventions and during transport to the hospital for acute myocardial infarction. Cardioprotective signaling has been extensively characterized in animal experiments. ⋯ URL: http://www.clinicaltrials.gov. Unique identifier: NCT01406678.