Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
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Case Reports
[Successful therapy of ulcerated necrobiosis lipoidica non diabeticorum with cyclosporine A].
Necrobiosis lipoidica is an inflammatory granulomatous skin disease of unknown etiology which is associated with diabetes mellitus in about 60% of the patients. In 15-35% of the affected patients painful ulcerations may occur after minimal trauma which can be extremely refractory to therapy. ⋯ We report on a 68-year-old patient with an 18 year history of ulcerated necrobiosis lipoidica non diabeticorum of both lower limbs, which responded to systemic cyclosporine A. Based on this case, we discuss the role of cyclosporine A in patients with necrobiosis lipoidica in the context of the disease etiology.