Diseases of the colon and rectum
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Randomized Controlled Trial Multicenter Study
Does adjuvant antibiotic treatment after drainage of anorectal abscess prevent development of anal fistulas? A randomized, placebo-controlled, double-blind, multicenter study.
The risk of fistula formation is a major concern after incision and drainage of an anorectal abscess. ⋯ Antibiotic treatment following the drainage of an anorectal abscess has no protective effect regarding risk of fistula formation.
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Multicenter Study Comparative Study
Primary colectomy in patients with stage IV colon cancer and unresectable distant metastases improves overall survival: results of a multicentric study.
Whether patients with stage IV colon cancer and unresectable distant metastases should be managed by primary colectomy followed by chemotherapy or immediate chemotherapy without resection of the primary tumor is still controversial. ⋯ In a selected population of patients with colon cancer and unresectable synchronous distant metastases, immediate colectomy followed by chemotherapy in association with targeted therapy was associated with longer overall survival. This strategy appears to be the most appropriate, especially for those with good performance status, well-differentiated tumors, and synchronous liver metastases only.
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Randomized Controlled Trial
The use of silver nylon in preventing surgical site infections following colon and rectal surgery.
Patients who undergo colorectal surgery have up to a 30% chance of developing a surgical site infection postoperatively. Silverlon is a silver nylon dressing designed to prevent surgical site infections, but only anecdotal evidence has previously supported its efficacy. ⋯ Silver nylon is safe and effective in preventing surgical site infection following colorectal surgery.