Diseases of the colon and rectum
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Randomized Controlled Trial Clinical Trial
Is routine cavity drainage necessary in Karydakis flap operation? A prospective, randomized trial.
Different surgical techniques for pilonidal disease have been described in the literature. In this study our aim was to evaluate the influence of routine cavity drainage in the Karydakis flap technique. ⋯ The present study indicates that routine cavity drainage reduces the incidence of fluid collection after the Karydakis flap operation.
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PTEN (phosphatase and tensin homologue deleted in chromosome 10) is a candidate tumor suppressor gene. Mutations of this gene are responsible for PTEN hamartoma tumor syndromes, including Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, Proteus syndrome, and Proteus -like syndromes. Recently, PTEN mutations were identified in several human neoplasms. We analyzed the DNA of various organs and lesions in Korean patients with Cowden syndrome, their family members, and patients with familial adenomatous polyposis for germline or somatic PTEN mutations. ⋯ We have identified two new germline PTEN mutations in Korean patients with Cowden syndrome. Mutations in the introns and regulatory regions of the PTEN gene may be present in additional patients with Cowden syndrome and polyposis syndrome.
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Mechanical bowel preparation or not? Outcome of a multicenter, randomized trial in elective open colon surgery.
Mechanical bowel preparation is common practice in elective colon surgery. In recent literature the value of this procedure is under discussion. To verify the value of mechanical bowel preparation in elective open colon surgery, a randomized clinical trial was conducted. ⋯ In the present study we could not detect a difference in outcome parameters between patients receiving mechanical bowel preparation in elective open colon surgery and patients without preoperative treatment of the bowel. The present study, although underpowered, did not show a difference in the primary outcome of bacterial wound cultures between patients receiving preoperative mechanical bowel preparation and patients receiving no preoperative bowel treatment. We conclude that there may be no need to continue the use of mechanical bowel preparation in elective open colon surgery.
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Comparative Study
The effect of preoperative radiotherapy on systemic collagen deposition and postoperative infective complications in rectal cancer patients.
Preoperative, high-dose radiotherapy for rectal cancer reduces local recurrence rates and improves overall survival. However, adverse effects in varying degrees include impaired wound healing and local infection. This study investigates the influence of preoperative, high-dose radiotherapy on subcutaneous accumulation of collagen in a primary rectal cancer group operated on with or without adjuvant radiotherapy. ⋯ High-dose, short-term radiotherapy does not have a systemic effect on collagen accumulation, but a significant reduction is manifested in infected patients. Radiotherapy also impairs leukocyte production and increases the postoperative infective complication rate.
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Case Reports
Spontaneous colonic mesenteric hemorrhage: report of an unusual case of abdominal apoplexy.
We describe a case of idiopathic abdominal apoplexy secondary to a spontaneous mesocolic bleed. Preoperative computed tomography of the abdomen suggested a ruptured colonic mass at the splenic flexure. ⋯ Idiopathic abdominal apoplexy is rare, the reported mortality has historically been high, and a short hospital stay and rapid, complete recovery are uncommon, although outcomes may be improving in recent years. We present such a case and examine the clinical presentation, management, and prognosis through literature review.