Fertility and sterility
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Fertility and sterility · Jul 2014
Long-term influence of combined oral contraceptive use on the clinical course of relapsing-remitting multiple sclerosis.
To assess the long-term effects of combined oral contraceptives (COCs) on the clinical course of relapsing-remitting multiple sclerosis (RRMS), focusing on disability progression and evolution to secondary-progressive multiple sclerosis (SPMS). ⋯ Our results suggest that COC use is associated with a less severe disease and less severe evolution. Whether different doses or types of progestin may have different effects remains to be defined.
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Fertility and sterility · Jul 2014
Dynamics of nitric oxide, altered follicular microenvironment, and oocyte quality in women with endometriosis.
To study follicular microenvironment in terms of free radical dynamics, oocyte quality, and assisted reproductive technology (ART) outcomes among women with (group A) and without (group B) endometriosis. ⋯ Increased protein nitration, GC apoptosis, resistance to IVM, and oocyte aging indicate the involvement of oxidative dysregulation of NO in the pathophysiology of altered follicular milieu and poor oocyte quality in women with endometriosis.