Fertility and sterility
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Fertility and sterility · Feb 2021
Randomized Controlled TrialResponsiveness and thresholds for clinically meaningful changes in worst pain numerical rating scale for dysmenorrhea and nonmenstrual pelvic pain in women with moderate to severe endometriosis.
To evaluate the utility, responsiveness, and thresholds for clinically meaningful change of a numerical rating scale for worst pain associated with dysmenorrhea (NRS-DYS) and nonmenstrual pelvic pain (NRS-NMPP) in women with moderate to severe endometriosis-associated pain. ⋯ This study demonstrated the utility and responsiveness of separate numerical rating scales to assess worst pain for dysmenorrhea and NMPP in women with moderate to severe endometriosis-associated pain and identified initial thresholds for clinically meaningful change.
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Fertility and sterility · Feb 2021
Randomized Controlled Trial Multicenter StudyRelugolix, an oral gonadotropin-releasing hormone receptor antagonist, reduces endometriosis-associated pain in a dose-response manner: a randomized, double-blind, placebo-controlled study.
To evaluate the efficacy and safety of three dose levels of relugolix, a gonadotropin-releasing hormone receptor antagonist, compared with placebo and leuprorelin in women with endometriosis-associated pain. ⋯ NCT01458301.
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Fertility and sterility · Sep 2019
Randomized Controlled Trial Multicenter StudyImpact of elagolix on work loss due to endometriosis-associated pain: estimates based on the results of two phase III clinical trials.
To estimate the impact of elagolix on work loss due to endometriosis-associated pain. ⋯ NCT01620528 (EM-I) and NCT01931670 (EM-II).
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Fertility and sterility · Aug 2019
Randomized Controlled Trial Multicenter StudyImpact of elagolix treatment on fatigue experienced by women with moderate to severe pain associated with endometriosis.
To evaluate the efficacy of elagolix, an oral GnRH antagonist, for the reduction of fatigue in women with moderate or severe endometriosis-associated pain. ⋯ In women with moderate to severe endometriosis related pain, elagolix significantly reduces fatigue levels.