Adv Exp Med Biol
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Randomized Controlled Trial Comparative Study
Comparison of Small Bore Catheter Aspiration and Chest Tube Drainage in the Management of Spontaneous Pneumothorax.
Beside standard chest tube drainage other less invasive techniques have been used in the management of patients with an acute episode of spontaneous pneumothorax. The aim of the study was to evaluate the short term effect of spontaneous pneumothorax treatment with small-bore pleural catheter and manual aspiration as compared to large-bore chest tube drainage. Patients with an episode of pneumothorax who required pleural intervention were enrolled in the study and randomly assigned to one of the treatment arms: (1) small-bore pleural catheter (8 Fr) with manual aspiration; (2) standard chest tube drainage (20-24 Fr). ⋯ First line treatment success rates were 64% and 82% in the manual aspiration and chest tube drainage groups, respectively; the difference was insignificant. Median time of treatment with small bore catheter was significantly shorter than conventional chest tube drainage (2.0 vs. 6.0 days; p<0.05). Our results show that treatment of spontaneous pneumothorax with small-bore pleural catheter and manual aspiration might be similarly effective as is chest tube drainage in terms of immediate lung re-expansion.
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Randomized Controlled Trial
Indacaterol add-on therapy improves lung function, exercise capacity and life quality of COPD patients.
Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory condition, involving airways and lung parenchyma. The disease leads to airflow limitation, and pulmonary hyperinflation, resulting in dyspnea, decreased exercise tolerance, and impaired quality of life. COPD pharmacotherapy guidelines are based on a combination of long-acting beta2-agonists (LABA), long-acting antimuscarinic agents (LAMA) and methyloxantins. ⋯ We also found that the degree of desaturation before and after 6MWD, and fatigue levels significantly improved in the indacaterol group. The patients' quality of life also changed favorably in the indacaterol treatment arm. We conclude that the add-on therapy with indacaterol exerts positive effects in COPD patients.
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Randomized Controlled Trial
The effect of two different intermittent hypoxia protocols on ventilatory responses to hypoxia and carbon dioxide at rest.
Intermittent hypoxia (IH) consists of bouts of hypoxic exposure interspersed with normoxic intervals. The optimal IH regime for increasing the ventilatory response in humans is unknown, although in animals there is evidence that multiple short duration bouts of intermittent hypoxia (SDIH) provoke larger changes in chemosensitivity than longer duration bouts of intermittent hypoxia (LDIH). The purpose of this study was to compare responses to both hypercapnia and hypoxia between the two protocols. ⋯ Following each 7-day IH protocol, mean HVR was significantly (p < 0.05) increased by 67% and 49% (for LDIH and SDIH, respectively). One week post IH, HVR values were not different from pre-values. HCVR was increased significantly by the LDIH protocol by 44.1% (p < 0.01) and remained elevated by 41.5% at 7 days post (p < 0.01). The changes following the SDIH protocol were smaller (20.7% and 13.5%, at 1 and 7 days post IH, respectively) and not significant. The HCVR remained elevated 7 days following IH (26.7%, p < 0.01). In both the hyperoxic and hypoxic modified rebreathing tests, the CO2 sensitivity was unchanged by either intervention. In hypoxia, the CO2 threshold was significantly reduced following both protocols (p < 0.05). LDIH reduced the threshold by 1.60mmHg, whereas following SDIH it was reduced by 1.98mmHg. Under hyperoxic conditions, LDIH reduced the CO2 threshold by 2.06 mmHg, and SDIH caused a reduction of 2.53 mmHg. There were no significant differences between the two IH protocols for any of the above measures. A 7-day intermittent hypoxic protocol consisting of daily 60-minute exposures to normobaric poikilocapnic hypoxia caused increases in HVR and HCVR. This protocol caused a left-shift in the CO2 threshold but no change in CO2 sensitivity by the modified rebreathing protocol. Neither protocol proved superior in effecting these changes in the resting control of breathing.
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Randomized Controlled Trial Clinical Trial
A population-based trial of beta-carotene chemoprevention of head and neck cancer.