Curr Ther Res Clin E
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Curr Ther Res Clin E · Nov 2003
Treatment of diaphragmatic fatigue with inhaled aminophylline therapy in an experimental canine model: an open-label, dose-ranging, pharmacologic study.
Diaphragmatic fatigue may contribute to the development of respiratory failure. Although aminophylline administered IV has been widely used to treat diaphragmatic fatigue, to date it has not been used in aerosol formulation for this purpose. ⋯ Inhaled aminophylline significantly improved contractility of fatigued diaphragm in a dose-related manner in this experimental canine model (P<0.05). Its potent effect may be caused by transmembrane calcium movement.