Exp Ther Med
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Postoperative exacerbation of interstitial pneumonia in patients with lung cancer and interstitial lung disease has emerged as a serious problem. Therefore, the risk factors for postoperative exacerbation of interstitial pneumonia in patients with interstitial lung disease must be identified. We analyzed 22 patients diagnosed as having lung cancer with interstitial lung disease who underwent surgical treatment at the Kitasato University Hospital. ⋯ Almost all patients with postoperative exacerbation underwent lobectomy, had elevated KL-6 levels in the serum pre-operatively, and had significantly advanced stages of disease. Of the 5 patients with postoperative exacerbation, 2 had a history of inflammation prior to their exacerbation: 1 had a common cold and the other pyothorax. In patients with lung cancer and interstitial lung disease, advanced age, advanced stage disease, no postoperative administration of steroid and a pre-operative episode of inflammation are all risk factors for postoperative exacerbation of interstitial pneumonia.
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Acute kidney injury (AKI) is a common clinical problem which occurs in critically ill patients. Sepsis is now recognized as the most important contributing factor to AKI in this population. In clinical practice, certain studies have explored the urine neutrophil gelatinase-associated lipocalin (uNGAL) and the urine kidney injury molecule-1 (uKIM-1) as diagnostic and prognostic indices of AKI. ⋯ On the other hand, there was no statistical difference in event-free survival between patients with and without higher serum creatinine, creatinine clearance and uKIM-1 (data not shown). In conclusion, uNGAL may be a promising predictor for septic patients with AKI, resulting in a clear increase in 180-day mortality. Further clinical evaluation of uNGAL is underway.