J Transl Med
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Postural tachycardia syndrome (POTS) is a heterogeneous disorder that creates challenges for treatment. Beta-blocker was one of the most commonly used drugs, but it is inconsistently effective. The purpose of this study is to explore whether orthostatic plasma norepinephrine level could be an indicator of therapeutic effectiveness of metoprolol for POTS in children. ⋯ Orthostatic plasma norepinephrine level of>3.59 pg/ml was an indicator of the effectiveness of metoprolol therapy for POTS in children and adolescents.