Undersea Hyperbar M
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Undersea Hyperbar M · Nov 2011
Randomized Controlled TrialEffects of early hyperbaric oxygen therapy on clinical outcome in postoperative patients with intracranial aneurysm.
To investigate the effects of hyperbaric oxygen (HBO2) in postoperative patients with intracranial aneurysm. ⋯ Early HBO2 appears to be beneficial asan adjunctive treatment of postoperative intracranial aneurysm. Attenuating postoperative CVS, brain edema, and cerebral ischemia contributes to the effectiveness of HBO2.
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Undersea Hyperbar M · Nov 2011
Tissue oxygenation and microvascular hemodynamics in experimental arterial gas embolism.
Microvascular hemodynamic responses to arterial gas embolism (AGE) and local oxygen tensions (PO2) have never been evaluated in vivo using intravital microscopy. A system was implemented to study AGE in real time using brightfield and phosphorescence microscopy as well as laser-induced microvessel occlusion. Bubble dynamics, microhemodynamics and oxygenation were studied following AGE in 61 microvessels and 41 interstitial spaces from 19 anesthetized rats. ⋯ However, certain areas did not become fully hypoxic since redistribution of blood allowed oxygen to be supplied by nearby microvessels with blood (or plasma) flow or tissue gas diffusion. A linear correlation between interstitial and intravascular PO2 was found during baseline and after AGE. Because some microvessels remain flowing even after AGE, our observations suggest that intravascular therapeutic agents administered during severe AGE may reach microvascular networks and provide additional oxygenation to tissue areas where blood flow is compromised due to occlusion of some microvessels.