Undersea Hyperbar M
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Undersea Hyperbar M · Nov 2011
Randomized Controlled TrialEffects of early hyperbaric oxygen therapy on clinical outcome in postoperative patients with intracranial aneurysm.
To investigate the effects of hyperbaric oxygen (HBO2) in postoperative patients with intracranial aneurysm. ⋯ Early HBO2 appears to be beneficial asan adjunctive treatment of postoperative intracranial aneurysm. Attenuating postoperative CVS, brain edema, and cerebral ischemia contributes to the effectiveness of HBO2.
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Undersea Hyperbar M · Nov 2011
Tissue oxygenation and microvascular hemodynamics in experimental arterial gas embolism.
Microvascular hemodynamic responses to arterial gas embolism (AGE) and local oxygen tensions (PO2) have never been evaluated in vivo using intravital microscopy. A system was implemented to study AGE in real time using brightfield and phosphorescence microscopy as well as laser-induced microvessel occlusion. Bubble dynamics, microhemodynamics and oxygenation were studied following AGE in 61 microvessels and 41 interstitial spaces from 19 anesthetized rats. ⋯ However, certain areas did not become fully hypoxic since redistribution of blood allowed oxygen to be supplied by nearby microvessels with blood (or plasma) flow or tissue gas diffusion. A linear correlation between interstitial and intravascular PO2 was found during baseline and after AGE. Because some microvessels remain flowing even after AGE, our observations suggest that intravascular therapeutic agents administered during severe AGE may reach microvascular networks and provide additional oxygenation to tissue areas where blood flow is compromised due to occlusion of some microvessels.
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Undersea Hyperbar M · Sep 2011
Hyperbaric oxygen for neurologic indications--action plan for multicenter trials in: stroke, traumatic brain injury, radiation encephalopathy & status migrainosus.
The 2008 Toronto Hyperbaric Medicine Symposium was convened to discuss research into neurologic indications for hyperbaric oxygen therapy (HBO2T). Four topics were particularly addressed: acute ischemic stroke; acute traumatic brain injury; brain radiation necrosis; and status migrainosus. Four multicenter trials were designed and proposed to evaluate the efficacy of HBO2T for these indications and are presented here in addition to brief reviews of the rationale behind each.
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Undersea Hyperbar M · Jul 2011
Case ReportsHyperbaric oxygen treatment to eliminate a large venous air embolism: a case study.
Gas embolism, the entry of gas into vascular structures, can result in serious morbidity and death. It is an inadvertent clinical problem, but it also occurs in non-clinical environments. Gas embolisms result from procedures performed in almost all clinical specialties, thus making it a problem about which all clinicians should be aware. ⋯ For venous gas embolisms surgical removal is recommended, while for arterial embolisms, HBO2T is highly recommended. Here we report on a patient who inadvertently received a venous infusion of 150 ml air resulting in a major embolism, and who underwent HBO2T, recovered well, and suffered no adverse events. This result suggests that it is important to consider HBO2T as a recommended application for patients with venous embolisms.
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Undersea Hyperbar M · Jul 2011
Editorial CommentHydroxycobalamin, hyperbaric oxygen and cyanide poisoning.