J Trauma
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Controlled Clinical Trial
An open-label study to evaluate the safety and efficacy of tissue plasminogen activator in treatment of severe frostbite.
Severe frostbite can have devastating consequences with loss of limbs and digits. One of the mechanisms of cold injury to human tissue is vascular thrombosis. The effect of tissue plasminogen activator (tPA) and heparin in limb and digit preservation in severe frostbite patients has not been previously studied. ⋯ Intravenous tPA and heparin after rapid rewarming is safe and reduced predicted digit amputations considerably. Patients with no response to thrombolytic therapy were those with more than 24 hours of cold exposure, warm ischemia times greater than 6 hours, or evidence of multiple freeze-thaw cycles. Our algorithm for treatment of severe frostbite now includes use of i.v. tPA for patients without contraindications.
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The objective of this study was to investigate serial changes in leukocyte deformability and rheologic properties of whole blood in patients with sepsis or trauma. ⋯ We conclude that leukocyte deformability decreases in patients with sepsis or severe trauma and that this change negatively affects rheologic properties of whole blood.
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Substances that inhibit Na/K ATPase activity appear in plasma during severe septic shock causing Na and fluid to move into cells and K to move out, resulting in cell swelling and an elevation of plasma K. These changes contribute to the morbidity of sepsis. Recently, we reported that inosine and other purine nucleosides stimulate Na/K ATPase activity, prolong survival in hemorrhagic shock, and lower the plasma potassium in that condition. Here, we determine whether inosine prolongs survival in lipopolysaccharide-induced sepsis shock. ⋯ Inosine prevents mortality in lipopolysaccharide-induced septic shock in rats. The mechanism of action must be intracellular, as blockers of the equilibrative nucleoside transporter prevented prolonged survival with inosine.
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Multicenter Study Clinical Trial
Surgeon-performed bedside organ assessment with sonography after trauma (BOAST): a pilot study from the WTA Multicenter Group.
Although nonoperative management of solid organ injuries is a well-accepted practice, a rapid method to assess the progression of the injury, the early development of organ-related complications, and the frequency with which follow-up computed tomography (CT) scans are needed has yet to be determined. The use of ultrasound in this setting may provide information that would improve the rate of organ salvage and decrease the patient's morbidity. The objectives of this study were to determine whether surgeons could successfully use a bedside organ assessment with sonography after trauma (BOAST) examination to: (1) detect a solid organ injury; and (2) assess for changes in the size of the organ injury, an increase or decrease in hemoperitoneum, and the development of organ-related complications. ⋯ (1) BOAST has limitations in identifying solid organ injuries, especially those that are lower grade; (2) the US heme score is a valuable adjunct to the clinical examination in following patients with high-grade solid organ injuries and a dropping hemoglobin; and (3) although uncommon, organ-related complications may be identified using BOAST.
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Uncrossmatched type-O packed red blood cells (UORBC) are recommended for immediate transfusion in hemorrhaging trauma patients. The potential for alloimmunization with this technique is controversial, and has been reported to be as high as 80%. We examined a 1-year experience with UORBC transfusion to determine the incidence of allergic reaction and alloimmunization. ⋯ The need for UORBC is associated with significant injury and the need for subsequent massive transfusion. In this largest reported trauma series, the use of UORBC enabled rapid administration of red cells to hemorrhaging patients, without discernible risk for transfusion-related complications. The rate of seroconversion of Rh-patients is lower than reported in the literature, perhaps due to immune suppression associated with hemorrhagic shock.