Gastroenterology
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Randomized Controlled Trial Comparative Study Clinical Trial
A 5HT3 antagonist corrects the postprandial colonic hypertonic response in carcinoid diarrhea.
Carcinoid patients show a hypertonic colonic motor response postprandially. Ondansetron reduces postprandial colonic tone in health. It was hypothesized that ondansetron, a selective 5HT3 antagonist, corrects the colonic motor response to eating in carcinoid diarrhea. ⋯ Ondastetron reduces the postprandial colonic hypertonic response in carcinoid diarrhea to levels previously reported in health; further clinical studies of this class of antagonists in carcinoid diarrhea appear warranted.