Gastroenterology
-
Randomized Controlled Trial Clinical Trial
The MACH2 study: role of omeprazole in eradication of Helicobacter pylori with 1-week triple therapies.
The role of omeprazole in triple therapy and the impact of Helicobacter pylori resistance on treatment outcome are not established. This study investigated the role of omeprazole and influence of primary H. pylori resistance on eradication and development of secondary resistance. ⋯ Addition of omeprazole achieves high eradication rates, reduces the impact of primary resistance, and may decrease the risk of secondary resistance compared with regimens containing only two antibiotics.
-
Risk factors of metachronous liver metastases and death are not well known in patients with the Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1. These factors were retrospectively determined in 77 patients. ⋯ Large pancreatic tumors are predictive of the development of metachronous liver metastases, and surgery does not seem to prevent them.