J Invest Allerg Clin
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J Invest Allerg Clin · Jan 2011
Comparative StudyEnhanced diagnosis of pollen allergy using specific immunoglobulin E determination to detect major allergens and panallergens.
Pollen is one of the main causes of allergic sensitization. It is not easy to make an etiological diagnosis of pollen-allergic patients because of the wide variety of sensitizing pollens, association with food allergy, and increasing incidence of polysensitization, which may result from the presence of allergens that are common to different species, as is the case of panallergens. ⋯ Sensitization to panallergens could be a confounding factor in the diagnosis of polysensitized pollen-allergic patients as well as a marker for food allergy. However, more studies are required to further investigate the role of these molecules.
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J Invest Allerg Clin · Jan 2011
Chronic autoimmune urticaria: frequency and association with immunological markers.
Chronic autoimmune urticaria (CAU), a subgroup of chronic idiopathic urticaria (CIU), is characterized by severe and persistent wheals accompanied by redness and itching. Diagnosis is almost completely based on clinical suspicion and the results of the autologous serum skin test (ASST). ⋯ ASST remains a baseline diagnostic test for CAU. Patients with CAU had more frequent attacks and higher antithyroid antibody titers and peripheral B-cell percentages, as well as lower absolute eosinophil counts and serum IgE concentrations.
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J Invest Allerg Clin · Jan 2011
Case ReportsEosinophilic esophagitis, celiac disease, and immunoglobulin E-mediated allergy in a 2-year-old child.
Celiac disease, eosinophilic esophagitis, and urticaria are 3 manifestations of food allergy with different pathogenic mechanisms. We report the case of a 2-year-old child with digestive symptoms, slow growth, and severe asthma. The results of skin prick tests were positive to several foods. ⋯ A gluten-free diet is the basis of treatment of celiac disease, but the role of an elimination diet in eosinophilic esophagitis is not well established. Our patient also developed urticaria when exposed to milk and egg. We present, to our knowledge, the first report of a patient with celiac disease, eosinophilic esophagitis, and immediate-type immunoglobulin E-mediated food allergy.