J Exp Clin Canc Res
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J Exp Clin Canc Res · Mar 2016
Phosphatidylserine exposing-platelets and microparticles promote procoagulant activity in colon cancer patients.
Colon cancer is invariably accompanied by altered coagulation activity; however, the precise role of phosphatidylserine (PS) in the hypercoagulable state of colon cancer patients remains unclear. We explored the exposure of PS on platelets and microparticles (MPs), and evaluate its role in procoagulant activity in colon cancer patients. ⋯ Our results suggest that PS-positive platelets and MPs contribute to hypercoagulability and represent a potential therapeutic target to prevent coagulation in patients with colon cancer.