Mol Cancer

The most recent articles from: Mol Cancer April 2013

Mol Cancer · Apr 2013

MicroRNA-32 (miR-32) regulates phosphatase and tensin homologue (PTEN) expression and promotes growth, migration, and invasion in colorectal carcinoma cells.

Colorectal carcinoma (CRC) is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRNAs, miRs) play important roles in carcinogenesis. MiR-32 has been shown to be upregulated in CRC. In this study, we identified the potential effects of miR-32 on some important biological properties of CRC cells, and clarified the regulation of PTEN by miR-32. ⋯ Our results demonstrated that miR-32 was involved in tumorigenesis of CRC at least in part by suppression of PTEN.

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