Bmc Musculoskel Dis
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Bmc Musculoskel Dis · Jul 2009
Randomized Controlled Trial Comparative StudyThe Intensive Diet and Exercise for Arthritis (IDEA) trial: design and rationale.
Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently conducting a study to test the hypothesis that intensive weight loss will reduce inflammation and joint loads sufficiently to alter disease progression, either with or without exercise. This article describes the intervention, the empirical evidence to support it, and test-retest reliability data. ⋯ The IDEA trial has the potential to enhance our understanding of the OA disease process, refine weight loss and exercise recommendations in this prevalent disease, and reduce the burden of disability.