American journal of veterinary research
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To determine pharmacokinetics, renal effects, and effect on atracurium-induced neuromuscular blockade of a high dose of gentamicin in isoflurane-anesthetized dogs. ⋯ Mean values for apparent volume of distribution and total body clearance of gentamicin were similar to values in unanesthetized dogs. Mean maximal serum concentration of gentamicin was greater than that in unanesthetized dogs. Renal function was unaffected. Gentamicin potentiated atracurium-induced neuromuscular blockade, but did not affect recovery time.
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To better characterize the source of the large nonparietal secretory response to pentagastrin (PG) expressed in gastric contents of cannulated horses. ⋯ PG induces a marked, nonparietal, secretory response into the gastric contents of cannulated horses. The volume and [Na+] of this response was maintained after pretreatment with OME, although the pH of the contents became basic, indicating that this nonparietal response is not mediated by an OME-sensitive proton pump.