American journal of veterinary research
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To determine pharmacokinetics, renal effects, and effect on atracurium-induced neuromuscular blockade of a high dose of gentamicin in isoflurane-anesthetized dogs. ⋯ Mean values for apparent volume of distribution and total body clearance of gentamicin were similar to values in unanesthetized dogs. Mean maximal serum concentration of gentamicin was greater than that in unanesthetized dogs. Renal function was unaffected. Gentamicin potentiated atracurium-induced neuromuscular blockade, but did not affect recovery time.
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To better characterize the source of the large nonparietal secretory response to pentagastrin (PG) expressed in gastric contents of cannulated horses. ⋯ PG induces a marked, nonparietal, secretory response into the gastric contents of cannulated horses. The volume and [Na+] of this response was maintained after pretreatment with OME, although the pH of the contents became basic, indicating that this nonparietal response is not mediated by an OME-sensitive proton pump.
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To examine the physiologic and pharmacokinetic effects of a technique of total intravenous anesthesia in ponies. ⋯ Ketamine-climazolan infusion appeared suitable for maintenance of anesthesia in ponies, although recovery was not ideal in 2 of 6 ponies.
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Randomized Controlled Trial Comparative Study Clinical Trial
Disposition of transdermally administered fentanyl in dogs.
To evaluate the disposition of fentanyl after i.v. and transdermal administrations. The hypothesis was that transdermal administration of fentanyl would result in a measurable plasma opioid concentration. ⋯ Transdermally administered fentanyl has the potential to be a clinically useful analgesic regimen in dogs, and further evaluation of its analgesic actions and potential side effects warranted
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Comparative Study
Anesthesia induced in pigs by use of a combination of medetomidine, butorphanol, and ketamine and its reversal by administration of atipamezole.
To develop an IM administrable anesthetic combination for pigs. ⋯ Medetomidine, butorphanol, and ketamine-induced anesthesia is available for short-term major surgery in pigs.