Hepato Gastroenterol
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Hepato Gastroenterol · Mar 2009
COMT gene Val158Met polymorphism influences the severity of intestinal metaplasia in H. pylori infected older subjects.
A complex interaction of host genetic and environmental factors may be relevant in the development of Helocobacter pylori (H. pylori) related gastroduodenal diseases. Catechol-O-methyltransferase (COMT) is expressed catalyzes the methylation of various endobiotic and xenobiotic substances and thus might protect DNA from oxidative damage. We aimed to clarify the effect of COMT functional polymorphism on the severity of histological gastritis in a Japanese population. ⋯ Our data suggest that COMT gene 158Met polymorphism is associate with a reduced risk of developing more severe intestinal metaplasia in H. pylori infected older subjects.
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Hepato Gastroenterol · Mar 2009
Case ReportsAnte-situm liver resection in recurrent liver metastasis from colorectal cancer.
Surgical resection of liver metastases from colorectal cancer can offer long-term survival and cure in patients with metastatic colorectal cancer isolated to the liver. We present a case of a recurrent liver metastasis from rectal cancer, managed with ante-situm liver resection under total vascular exclusion and venovenous bypass with hypothermic perfusion. A 58-year-old man, who was diagnosed with liver metastasis from rectal cancer underwent a left lateral sectionectomy in January 2006. ⋯ The patient remains well without recurrence for 12 months after the last operation. Ante-situm technique made it easy to approach and completely removes the recurrent lesion locating at hardly accessible site and having the incomplete removal risk by conventional liver resection. The authors also reconfirmed that repeat hepatectomy is valuable in recurrent colorectal liver metastases.