Hepato Gastroenterol
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Hepato Gastroenterol · May 2015
Decreased Expression of MIR-134 and its Clinical Significance in Human Colorectal Cancer.
Dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of miR-134 has been found in some types of cancer. However, miR-134 expression and its clinical significance in colorectal cancer (CRC) have not been explored. The aim of this study was to explore the effects of miR-134 in CRC tumorigenesis and development. ⋯ These findings indicate that miR 134 may act as a tumor suppressor in CRC and would serve as a novel therapeutic agent for miR-based therapy.
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Hepato Gastroenterol · Mar 2015
Comparative StudyRed blood cell distribution width as a non-invasive marker for the assessment of inflammation in non-alcoholic steatohepatitis.
The aim of this study was to assess the association between red cell distribution width and inflammation in biopsy proven non-alcoholic steatohepatitis. ⋯ Red cell distribution width was a sensitive and specific method for the assessment of the inflammation in patients with non-alcoholic steatohepatitis.
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Hepato Gastroenterol · Mar 2015
Observational StudyManagement of severe blunt liver injuries by applying the damage control strategies with packing-oriented surgery: experiences at a single institution in Korea.
This study was conducted to investigate effective management strategies for patients with severe blunt liver injuries. ⋯ Although nonoperative management can first be pursued if the patient's condition allows for it, hemodynamic instability and evidence of peritonitis requires surgical management. Surgical management should abide by the damage control surgery principles that focus on packing to minimize surgical time, followed by aggressive critical care according to damage control resuscitation.
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Hepato Gastroenterol · Mar 2015
Review Meta AnalysisThe impact of anesthetic techniques on survival for patients with colorectal cancer: evidence based on six studies.
Epidural-supplemented general anesthesia is perceived as a more beneficial method over general anesthesia since it reduces incidence of side effects, provides better postoperative pain relief and lowers the possibility to use immunosuppressive anesthetics. However, previous prospective and retrospective studies reported conflicting results in the effects of epidural anesthesia on post-operative outcomes of colorectal cancer surgery. Therefore, this study aims to pool available evidence to assess the association between epidural anesthesia and the post- operative outcomes in this group of patients. ⋯ Although epidural anesthesia might not lead to improved recurrence free survival, it had significant benefit in improving overall survival and reducing all-cause of death. It might be a useful anesthetic technique for colorectal cancer patients undergoing surgery. However, prospective studies are required to confirm whether this benefit is causative with epidural anesthesia.
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Hepato Gastroenterol · Mar 2015
ReviewRisk, diagnosis and treatment to postoperative delirium in elderly patients with gastrointestinal cancers.
In recent years, more elderly patients with gastrointestinal cancers have been undergoing surgery. As one of main postoperative complications, postoperative delirium (POD) is harmful and difficult to prevent and treat. ⋯ However, health care providers still have many problems for POD to face in elderly,with gastrointestinal cancers during the clinical care. In this paper, Etiology, damages, prevention, diagnosis and treatment of POD in elderly with gastrointestinal cancer were reviewed, and the prospect of POD was also discussed.