Metabolism: clinical and experimental
The most recent articles from: April 2013
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Randomized Controlled Trial
Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
Glucocorticoids impair glucose tolerance by inducing insulin resistance. We investigated the dose-dependent effects of glucocorticoid treatment on islet-cell function in healthy males and studied the role of the autonomic nervous system. ⋯ We conclude that in addition to inducing insulin resistance, prednisolone treatment dose-dependently impaired islet-cell function. Altered sympathovagal balance may be related to these effects.