Minerva anestesiologica
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Minerva anestesiologica · Apr 1997
Randomized Controlled Trial Clinical TrialSpinal anesthesia with clonidine and bupivacaine in young humans: interactions and effects on the cardiovascular system.
Clonidine, an alpha 2 agonist, is known to prolong the action of local anesthetics, and to provide a satisfactory analgesia; hypotension and bradycardia have been observed after its intrathecal administration. The aim of our study was to determine whether intrathecal administration of clonidine can reduce the dose of local anesthetic, and the effects of clonidine on the cardiovascular system, and on arousal level. ⋯ In summary, the addition of clonidine to hyperbaric bupivacaine seems to be particularly useful in unilateral spinal anesthesia, exerting minimal influence on haemodynamic parameters, and guaranting a satisfactory postoperative analgesia.