Minerva anestesiologica
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Minerva anestesiologica · Mar 2013
Randomized Controlled TrialMedian effective dose (ED50) of paracetamol and nefopam for postoperative pain: isobolographic analysis of their antinociceptive interaction.
The analgesic efficacy of nefopam and of paracetamol has been shown in the postoperative period after mild- and moderate-pain surgery. The aim of this study was to define the median effective analgesic doses of each drug and of their combination, in order to determine the nature of their interaction. ⋯ The combination of nefopam and paracetamol produces effective analgesia with a synergistic interaction.